About Capstan Therapeutics

Capstan Therapeutics, Inc. is a privately held biotechnology company dedicated to advancing in vivo cell reprogramming. The core platform technology comprises proprietary targeted lipid nanoparticles (tLNPs) that are composed of LNPs conjugated with a recombinant protein binder, such as a monoclonal antibody. tLNPs are designed to deliver payloads, including mRNA or gene editing tools, capable of reprogramming specific cell types in vivo. The platform technology has the potential to generate transformative therapies with possible applications across a broad range of disease areas, including oncology, autoimmune disorders, fibrosis, and monogenic blood disorders.

The Opportunity

We are seeking a Research Associate I - II to perform mRNA production and purification.  The candidate will perform in vitro transcribed (IVT) mRNA production, mRNA purification, and analytical characterization under appropriate supervision.

Responsibilities & Duties:

• Perform production and purification of in vitro transcribed (IVT) mRNA
• Perform hands-on laboratory experiments involving filtration, chromatography, TFF, and other process development instrumentation
• Quality control analysis of mRNA product including gel electrophoresis, Dot blot, UV, etc.
• Develop new techniques for mRNA optimization and large-scale production of mRNA under supervision
• Maintain appropriate lab notebooks and electronic records
• Perform routine technical tasks including managing laboratory inventory, prepare stock reagents, and general lab maintenance

Requirements/Qualifications:

• B.S. or M.S. in Molecular Biology, Biochemistry, Biological Engineering, Chemistry, or related field with minimum 1-2+ years directly related experience.
• Basic knowledge and application of biologics and/or nucleic acid process development and scale up principles
• Detail oriented with strong written and verbal communication skills.
• Ability to work independently, within prescribed guidelines, and as a team member.
• Ability to draft routine reports and keep accurate records of work performed.
• Actively seeks opportunities to increase skills and expertise.
• Able to learn complex task with general instructions.
• Able to use experience to perform a variety of new techniques.
• Demonstrated ability to follow detailed directions in a research laboratory environment.
• Must be familiar with Microsoft Office applications.

Salary & Benefits Offerings:

• Salary range is $67,500 - $95,000 year depending on experience.
• Performance bonus & Equity
• 401k Match Program
• Healthcare Coverage
• Dental Coverage
• Vision Coverage
• Optional Dependent Care Account
• Flexible Spending Account (FSA)
• Paid Time Off (PTO)
• Company Paid Holidays
• Paid Sick Leave
• Onsite Fully Stocked Kitchens

If you are interested in hearing more, reach out to us. We believe that each team member will impact and improve the lives of those we work with, and those we work for—our patients.

Capstan is an equal opportunity employer. We value diversity and do not discriminate on the basis of race, religion, color, national origin, sex, gender, gender expression, sexual orientation, age, marital status, veteran status, or disability status. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform critical job functions, and to receive other benefits and privileges of employment.

Unsolicited resumes sent to Capstan from recruiters do not constitute any type of relationship between the recruiter and Capstan and do not obligate Capstan to pay fees should we hire from those resumes. We ask that external recruiters and/or agencies not contact or present candidates directly to our hiring managers or employees.